Quiz: Patchy, Irregular, Grayish Deposits on the Anterior Lens Capsule

A 72-year-old woman presents with progressive blurry vision and glare in her right eye. She has a history of hypertension but no known ocular disease. Visual acuity is 20/60 right eye and 20/40 left eye. Intraocular pressures are 26 mmHg right and 18 mmHg left. The pupil in the right eye dilates poorly despite maximal mydriasis. Slit-lamp examination reveals patchy, irregular, grayish deposits on the anterior lens capsule and mild iris transillumination defects. Gonioscopy shows an open angle with dense trabecular pigmentation.

Authors: Mathilde Gallant & Eliana-Ruobing Zhang

52 thoughts on “Quiz: Patchy, Irregular, Grayish Deposits on the Anterior Lens Capsule”

    • Deferential Diagnosis
      1. Pseudoexfoliation syndrome: Patchy pigments on the anterior lens capsule, High IOP, decreased vision
      2. Pigmentary Glaucoma

      Reply
  1. I would say slit a lamp exam and gonioscopy are part of the clinical exam and not really tests or investigation.

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  2. Completely disagree!
    If a 72-year-old woman presents with progressive blurry vision and glare in her right eye and there is significant cataract, then the most appropriate initial management in the affected eye is careful cataract surgery, not topical intraocular pressure-lowering medications.

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  3. I believe observation might also be a feasible option at this stage, especially if there is minimal or no optic nerve damage. Washing out the angles during cataract surgery is probably more valuable (and better QoL) to this 72-year-old patient than starting drops or other glaucoma treatment. Treatment can always be started if optic nerve damage pregresses. A cardiovasular workup is also advisable.

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  4. I am very happy to attend this quiz. It was an excellent knowledge-enhancing platform that helped me learn and improve my understanding. The quiz was informative, engaging, and well organized. Thank you for this wonderful opportunity and experience.

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  5. It is very important lesson with clear explanation of the findings and questions.
    Thank you
    Getenet Shumet
    Lecturer, Department optometry
    University of Gondar, Ethiopia

    Reply
  6. The primary challenges associated with pseudoexfoliation syndrome are poor pupil dilation and weakened lens zonules, which can result in lens instability, lens dislocation, capsular tears, and other complications. These factors significantly increase the risk of intraoperative complications during cataract surgery. Therefore, it is essential that the surgeon identifies the presence of pseudoexfoliation syndrome before surgery so that appropriate precautions and surgical strategies can be planned. For this reason, cataract surgery in patients with pseudoexfoliation syndrome is generally recommended to be performed by an experienced cataract surgeon, preferably the most senior surgeon available.

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  7. The gonioscopy and slit lamp examination were already described and initio and they do not “assess” the risk of glaucoma. The IOP and fundus information (neuro-retinal rim and nerve fiber layer) are the critical clinical details needed for glaucoma risk assessment at this stage.

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  8. This patchy grayish deposit are according to PEX syndrome (pseudo exfoliation syndrome)
    That increase with age(72 in this case) and occur more in females(woman in this case), and most importantly results in secondary open angle glaucoma (which explains high iop in this case and low vision), and lead to small pupil due to effect to iris dilator muscle, and in addition it cause challenges in cataract surgery like weak capsule and dialysis also.
    Thank you

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  9. Thank you cybersight to give me knowledge. I learned everyone you send me emails you motivated me , Now I know that LOXL1is the most strongly associated with pseudoexfloliation syndrome

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