Quiz: Perplexing Pigment

A 65-year-old Asian male was referred by his general ophthalmologist for high intraocular pressure (IOP) in the left eye secondary to pigment dispersion syndrome.

The patient was found to have unilateral high IOP of 52 mmHg in the left eye approximately three months ago. He did not experience pain or discomfort in the left eye during this period and he did not notice any subjective visual field changes. He did report long-standing floaters in both eyes, more pronounced in the left. On examination, the patient was found to have open angles in both eyes, described as “open angles with some pigment”. The patient was started on two glaucoma drops, Vyzulta® (latanoprostene bunod 0.024%) and the combination drop Azarga® (brinzolamide/timolol).

The patient returned a week later for an IOP measurement, which had reduced to 25 mmHg in the left eye. His ophthalmologist then performed a dilated fundus exam and observed an inferior retinal detachment at the far periphery. The ophthalmologist subsequently performed laser retinopexy and suggested that the retinal detachment might have been chronic because some pigment was already present at the border.

The patient continued his two glaucoma drops but the IOP remained elevated, fluctuating between 25-30 mmHg and the patient was therefore referred to a glaucoma subspecialist.

Past medical history (PMI): Hypertension and dyslipidemia.
Post ocular history (POH): Uneventful cataract surgeries with PCIOL in both eyes 5 years ago.
History of trauma: None.
Medications: Azarga BID and Vyzulta QHS for the left eye.

Examination:

Gonioscopy:

Author:  Dr. Marcelo Nicolela and Dr. Tianwei Ellen Zhou

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